LSU is the flagship school of the state of Louisiana, as well as the flagship institution of the Louisiana State University System, and is the most comprehensive university in Louisiana. In 2017, the university enrolled over 25,000 undergraduate and over 5,000 graduate students in 14 schools and colleges. Several of LSU's graduate schools, such as the E. J. Ourso College of Business and the Paul M. Hebert Law Center, have received national recognition in their respective fields of study. It is classified among “R1: Doctoral Universities – Very high research activity". Designated as a land-grant, sea-grant, and space-grant institution, LSU is also noted for its extensive research facilities, operating some 800 sponsored research projects funded by agencies such as the National Institutes of Health, the National Science Foundation, the National Endowment for the Humanities, and the National Aeronautics and Space Administration. LSU is one of eight universities in the United States with dental, law, veterinary, medical, and Master of Business Administration programs. The LSU School of Veterinary Medicine is one of only 30 veterinary schools in the country and the only one in Louisiana.

LSU's athletics department fields teams in 21 varsity sports (9 men's, 12 women's), and is a member of the NCAA (National Collegiate Athletic Association) and the SEC (Southeastern Conference). The university is represented by its mascot, Mike the Tiger.