Established in 1826, as London University, by founders inspired by the radical ideas of Jeremy Bentham, UCL was the first university institution to be established in London, and the first in England to be entirely secular and to admit students regardless of their religion. UCL also makes contested claims to being the third-oldest university in England and the first to admit women. In 1836, UCL became one of the two founding colleges of the University of London, which was granted a royal charter in the same year. It has grown through mergers, including with the Institute of Ophthalmology (in 1995), the Institute of Neurology (in 1997), the Royal Free Hospital Medical School (in 1998), the Eastman Dental Institute (in 1999), the School of Slavonic and East European Studies (in 1999), the School of Pharmacy (in 2012) and the Institute of Education (in 2014).

UCL has its main campus in the Bloomsbury area of central London, with a number of institutes and teaching hospitals elsewhere in central London and satellite campuses in Queen Elizabeth Olympic Park in Stratford, east London and in Doha, Qatar. UCL is organised into 11 constituent faculties, within which there are over 100 departments, institutes and research centres. UCL operates several museums and collections in a wide range of fields, including the Petrie Museum of Egyptian Archaeology and the Grant Museum of Zoology and Comparative Anatomy, and administers the annual Orwell Prize in political writing. In 2019/20, UCL had around 43,840 students and 16,400 staff (including around 7,100 academic staff and 840 professors) and had a total income of £1.54 billion, of which £468 million was from research grants and contracts.

UCL is a member of numerous academic organisations, including the Russell Group and the League of European Research Universities, and is part of UCL Partners, the world's largest academic health science centre. It is considered part of the “golden triangle" of research-intensive universities in southeast England. UCL has publishing and commercial activities including UCL Press, UCL Business and UCL Consultants.

UCL has many notable alumni, including the respective “Fathers of the Nation" of India, Kenya and Mauritius, the founders of Ghana, modern Japan and Nigeria, the inventor of the telephone, and one of the co-discoverers of the structure of DNA. UCL academics discovered five of the naturally occurring noble gases, discovered hormones, invented the vacuum tube, and made several foundational advances in modern statistics. As of 2020, 34 Nobel Prize winners and three Fields medalists have been affiliated with UCL as alumni, faculty or researchers.